Carmellose BP Grade
Ph Eur
Action and use: Â Excipient; bulk laxative.
DEFINITION
Polycarboxymethylether of cellulose.
CHARACTERS
Appearance: Â White or almost white powder, hygroscopic.
Solubility: Practically insoluble in anhydrous ethanol. It swells with water
to form a suspension and becomes viscid in 1 M sodium hydroxide.
IDENTIFICATION
A. pH 3.5 to 5.0.
Suspend 1.0 g in 100 mL of water R.
B. Infrared absorption spectrophotometry
TESTS
Chlorides: Maximum 0.36 per cent.
Sulfates: Maximum 0.72 per cent.
Heavy metals: Maximum 20 ppm.
Loss on drying: Maximum 8.0 per cent, determined on 1.000 g by drying in an
oven at 10C for 4 h.
Sulfated ash: Maximum 1.5 per cent, determined on 1.0 g.
